We focus on uncovering the cellular regulation of protein synthesis and post-transcriptional modific

SARS-CoV-2 viral proteins promote immune evasion by translational inhibition of MHC class I

JCC Hsu, JB Pawlak, P Han, D Sengupta, M Laurent-Rolle, P Cresswell 

(in preparation) 

CMPK2 restricts Zika virus replication by inhibiting viral translation

JB Pawlak, JCC Hsu , H Xia, P Han , HW Suh , TL Grove, J Morrison, PY Shi , P Cresswell,  Maudry Laurent-Rolle

Plos Pathogens 19(4): e1011286.

SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to down-regulate MHC-I surface expression

N Arshad, M Laurent-Rolle,  WS Ahmed,  JCC Hsu, Susan M Mitchell,  J Pawlak, D Sengupta, KH Biswas,  P Cresswell

Proceedings of the National Academy of Sciences 120 (1), e2208525120

Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication 

JCC Hsu, M Laurent-Rolle, JB Pawlak, H Xia, A Kunte, JS Hee, J Lim, LD Harris, JW Wood, GB Evans,  TL Grove, PY Shi,  SC Almo, P Cresswell

Molecular Cell 82 (9), 1631-1642. e6

Protocol for assessing of translational regulation in mammalian cell lines by OP-Puro labeling

JCC Hsu, JB Pawlak, M Laurent-Rolle, P Cresswell

STAR Protocols 3 (3), 101654

Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein

JCC Hsu, M Laurent-Rolle, JB Pawlak, CB Wilen, P Cresswell

Proceedings of the National Academy of Sciences 118 (24)

SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2

Q Lu, J Liu, S Zhao et al.

Immunity 54 (6), 1304-1319. e9

Prolonged incubation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a patient on rituximab therapy

AG Koff, M Laurent-Rolle, JCC Hsu, M Malinis

Infection Control & Hospital Epidemiology 42 (10), 1286-1288

Translational regulation of viral RNA in the type I interferon response

JCC Hsu*, M Laurent-Rolle, P Cresswell

Current Research in Virological Science 2, 100012

*Corresponding author

Long SARS-CoV-2 nucleocapsid sequences in blood monocytes collected soon after hospital admission 

N Pagano, M Laurent-Rolle, JCC Hsu, the Yale IMPACT Research Team, CBF Vogels, ND Grubaugh, L Manuelidis 

bioRxiv, 2020.12. 16.423113

Abstract B163: Regulation of translation by the interferon-induced antiviral protein viperin

JCC Hsu, M Laurent-Rolle, P Cresswell

Cancer Immunology Research 7 (2 Supplement), B163-B163

Oncoprotein AEG-1 is an endoplasmic reticulum RNA-binding protein whose interactome is enriched in organelle resident protein-encoding mRNAs

JCC Hsu, DW Reid, AM Hoffman, D Sarkar, CV Nicchitta

RNA 24 (5), 688-703

Proteome Expression: The Subcellular Organisation of Protein Synthesis

JCC Hsu, CV Nicchitta

Essentials of Life Science

Directly monitor protein rearrangement on a nanosecond-to-millisecond time-scale

EHL Chen, TTY Lu, JCC Hsu, YJ Tseng, TS Lim, RPY Chen

Scientific Reports 7 (1), 1-11

Multifunctional roles for the protein translocation machinery in RNA anchoring to the endoplasmic reticulum

S Jagannathan*, JCC Hsu*, DW Reid, Q Chen, WJ Thompson, AM Moseley, CV Nicchitta

Journal of Biological Chemistry 289 (37), 25907-25924

*These authors made an equal contribution

Thioflavin T and its photoirradiative derivatives: Exploring their spectroscopic properties in the absence and presence of amyloid fibrils

JCC Hsu, EHL Chen, RC Snoeberger III, FY Luh, TS Lim, CP Hsu, RPY Chen

Journal of Physical Chemistry B 117 (13), 3459-3468

*These authors made an equal contribution

Studying submicrosecond protein folding kinetics using a photolabile caging strategy and time‐resolved photoacoustic calorimetry

HL Chen*, JCC Hsu*, MH Viet, MS Li, CK Hu, CH Liu, FY Luh, SSW Chen, ESH Chang, AHJ Wang, MF Hsu, W Fann, RPY Chen

Proteins: Structure, Function, and Bioinformatics 78 (14), 2973-2983

*These authors made an equal contribution